Medical physics and biomedical engineering research at the Advanced X-ray Tomographic Imaging (AXTI, homophone of actie, meaning action in Dutch) lab focuses on novel image acquisition, processing and analysis techniques, physical and perceptual evaluation of image quality, radiation dosimetry, tomographic image reconstruction, and advanced computational simulation methods in diagnostic x-ray based imaging, especially for breast and body tomographic imaging.
The aim of the AXTI lab is to perform state-of-the-art, clinically relevant research by working side by side with clinicians from the Department of Radiology and Nuclear Medicine at Radboudumc and collaborating with commercial partners, medical physicists, and scientists from around the world.
Thanks to the group members covering a wide range of skills and expertise, the research performed by AXTI spans all stages of the medical imaging chain, from the physics of image generation to the development of Artificial Intelligence algorithms for image quality improvement and radiomics-based tumor characterization. Some of the projects that AXTI is involved in include characterization and optimization of advanced tomographic breast imaging methods for cancer detection, diagnosis, and therapy response monitoring improvement. In addition, novel radiation dose metrics for personalized dosimetry in breast imaging are being developed, and research is also being performed on optimizing and characterizing the technical and clinical performance of functional lung and cardiac CT.
AXTI is part of the “Women’s Cancers” research theme of the Radboud Institute for Health Sciences (RIHS). Our research is funded primarily by the National Institutes of Health of the USA, the Susan G. Komen Foundation for the Cure, the Netherlands Organisation for Scientific Research (NWO), and the European Research Council (ERC). The lab also works in close collaboration with industry (Siemens Healthineers and Canon Medical Systems) and with the Dutch Expert Centre for Screening (LRCB).