Myocardial infarction and ischemia is a very common and important cause of mortality and morbidity worldwide. To prevent these potential life-threatening consequences early detection of coronary artery disease is crucial. Nowadays, several non-invasive imaging techniques are available for early detection of coronary artery disease and cardiac ischemia.
Cardiac CT angiography and perfusion are imaging techniques that (1) combine both anatomical and functional information, and (2) are relatively widely available in the emergency setting. Cardiac CT angiography (CTA) depicts the coronary artery anatomy and pathology (coronary plaques/stenosis) while cardiac CT perfusion (CTP) can reveal cardiac ischemia on a segment basis. Combining cardiac CTA and CTP has been shown to result in good accuracy for diagnosis of cardiac ischemia. Besides their evident diagnostic value, cardiac CTA and CTP can guide therapeutic decisions: i.e., the use of conservative vs. invasive treatment.
In this PhD project, you will perform a clinical implementation study using cardiac CTP in patients with acute chest pain in the emergency department. During this study, the information from cardiac CTA and CTP will be used to determine if the patient can be discharged from the emergency department or has to be admitted to the hospital for further invasive workup/treatment. Besides clinical relevant outcome parameters, this study aims to optimize the CTP acquisition protocol with special attention for radiation dose and image quality.
Throughout the project you will collaborate closely with (cardiovascular) radiologists, cardiologists, CT radiographers, and physicists, as well as be a member of the AXTI lab team.
Please apply here
Nijmegen is the oldest Dutch city with a rich history and one of the liveliest city centers in the Netherlands. Radboud University has over 17,000 students. Radboud University Medical Centre (Radboudumc) is a leading academic center for medical science, education and health care with over 8,500 staff and 3,000 students. Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. The Department of Radiology and Nuclear Medicine is one of the most active research departments of the Radboudumc, where more than 100 researchers are continuously striving to optimize healthcare.